Ataxia-telangiectasia is a disorder characterized by descendants no coordination, expands capillaries, and increased possibility of infection. Increased possibility of infection in people with ataxia-telangiectasia due to failure of B lymphocyte function and T Often, the antibody levels of IgA and IgE classes are also less. Sinus and recurrent respiratory infections, often developed into pneumonia and lung diseases like chronic bronchitis. Risk of cancer, especially leukemia, brain tumors, and cancers of the stomach, increases.
Abnormalities in the cerebellum (which is not associated with disruption immunodefisiensi) cause there is no coordination (ataxia). There is no coordination usually develops when the child begins to walk but may withdraw up to age 4. Speaking skills to disappear, and the muscles progressively weaken, causing severe disability. Mental retardation may occur and develop. Between ages 1 and 6, capillaries in the skin and eyes become enlarged and visible. Enlarged capillaries (telangiectasia), called spider veins, usually most obvious in the eyes and ears. Endocrine systems may be affected, causing small testes (in boys), infertility, and diabetes.
Antibiotics and immune globulin to help prevent infection but do not reduce the problem in the nervous system. Ataxia-telangiectasia are usually developed to paralysis, dementia, and death, usually before the age of 30 years.
